They usually work well, but you would hate it if a hard drive failed. It's the most fragile part of a build and sucks if it breaks. Go for a smaller-storage WD Blue, then add on as you need.
I can't speak to everyone's experience, but here is mine:
I purchased two 3TB Seagate Barracudas 6 months ago and have been running them in a file server 24/7 since. I haven't had an issue.
Although, if you don't mind spending a bit extra, the WD Blacks have an awesome warranty. 5 years, no questions asked replacement warranty. WD literally freaks the fuck out when their Blacks fail.