Are all GPUs compatible with all motherboards? Is there something you have to look for to make sure that they'll fit together?

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All GPU's are compatible with all motherboards (except maybe some of the early computing stuff but why you'd be looking at that is beyond me) as the PCI design is standardised.

The only thing you'll need to be aware of is if your case can support the length of your GPU and that you have enough PCI slots in the case (shouldn't be an issue unless you're using a 3 slot card [rare] in a mITX case).

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