Those two options are for different purposes.
The itgb+lgtng + inv is for pvp purposes. With that obelisk you wont be able to go very far with him on WBU. Thor lacks survival so for pvp that option is very good on him.
CTP if destruction is a little more versitile. Altough it doesnt give him invincibility, it maintains the itgb wich is also usefuul for pvp. And the proc is essential for clearing high WBU stages.
If you dont have any more suitable characters for the destrucion, i would say the ctp is better.
Medusa has an advantage on satana cause she can go to lvl 70. If they're both ate 60, satana (depending on build of course) is better